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The Formula for Long-lasting Success

Calibra Bio Bioceramic Luting Cement makes it easier to achieve successful results.  More than a quarter of all crown procedures are replacements of existing crowns, and restorations can fail when marginal integrity is compromised due to microleakage. But the combined chemistry of calcium aluminate and glass ionomer gives Calibra Bio Bioceramic Luting Cement unique properties unlike any other cement on the market.

Nature knows how to create a better seal. In a three-year study, Calibra Bio Bioceramic Cement has been shown to enhance long term marginal integrity with no discoloration, sensitivity, secondary caries or loss of retention. And it saves procedure time by performing in the mouth’s naturally moist environment with no need for priming, bonding or conditioning


Why choose Calibra Bio?

Ease of Handling – moisture-tolerant and easy cleanup

Calcium Aluminate and Glass Ionomer combined chemistry - works well with moisture. It has easy cleanup and is less technique - sensitive.

Simplified Cementation System for Zirconia

No primers necessary. No bonding. No conditioning. One and done system. With retentive strength at the same level as self-adhesive resin cements.

Self-Repairing Hydroxyapatite (HA) Layer

Calibra Bio Bioceramic Luting Cement minimizes micro leakage and protects t he restoration's long-term marginal integrity. lf any future damage occurs, saliva in the oral environment interacts with cement at the margins to continuously repair the HA layer and enhance overall marginal integrity.

Seamless Adaptation

Calibra Bio Bioceramic Luting Cement solves the problem of imperfections in the dentin-cement interface by adding CA particles that dissolve to release calcium and aluminate ions. When the ions reach a sufficient concentration, hydrates crystallize around the remaining CA particles to create seamless adaptation toward the tooth structure.

Calcium Aluminate Chemistry (CAIO)

Unique chemistry (Calcium Aluminate and Glass Ionomer combined chemistry = Calcium Aluminate Ionomer or CAIO) protects restoration’s marginal integrity. Calibra Bio Cement also shows seamless adaptation at the cement-tooth interface.

A Bioactive Cement

Forms a self-repairing hydroxyapatite (HA) layer that can protect marginal integrity. If HA layer gets removed or damaged, HA at the cement-saliva interface continuously self-repairs to protect the marginal integrity of the restoration.

No shrinkage

Helps protect marginal integrity

No Hema. No BPA.

Safe cement

Bioceramic with Excellent Biocompatibility

Calcium Aluminate is bioceramic. Calibra Bio Cement’s unique chemistry provides no adverse effect on living tissue. It has excellent biocompatibility with good sealing abilities

The new cement category: Calcium Aluminate lonomer

Calibra Bio cement is a chemically bonded bioceramic cement with a hybrid water-based composition combining both calcium aluminate and well-known glass ionomer chemistry in one new cement category – Calcium Aluminate Ionomer.

Calibra Bio cement fulfills the ISO standard 9917-1 and is indicated for luting indirect restorations including high strength ceramic and metal-based inlays, onlays, crowns, bridges, and posts suitable for conventional cementation. The retentive strength of Calibra Bio cement has been tested by cementing various crown materials. Posterior crowns made of high-strength glass ceramic, zirconia, and metal alloy were cemented under consistent seating force on standardized crown preparations. Calibra Bio cement was compared to different cements including zinc phosphate, glass ionomer, and self-adhesive resin cements. After accelerated aging, the crowns were pull-tested in a universal testing machine to measure the retentive strength of each cement. The results showed the retention of Calibra Bio cement to be on the same level as self-adhesive resin cements (RelyX Unicem, RelyX Unicem 2).

In a clinical study, the handling properties as well as the working and setting time for Calibra Bio cement were favorable during cementation.1,3 The investigators were attracted to the ease of cement removal in one or few pieces without need to rush the clean-up. A total of 38 crowns and bridges were cemented on retentive preparations of 43 vital and in non-vital teeth. At the three-year recall no loss of retention, secondary caries or marginal discolorations were found. All restorations rated excellent for marginal integrity. In addition, no associated gingival inflammation or hypersensitivity was reported.

When the powder is mixed with the aqueous liquid in a capsule mixer/triturator, the resulting chemical reactions of the calcium aluminate (CA) and the reactive glass ionomer parts form a biocompatible cement material. The setting reaction of Calibra Bio cement roughly follows two different acid-base reactions:

  1. Glass ionomer reaction of polyacrylic acid with basic reactive glass
  2. Hydration of CA resulting in precipitation of crystals – katoite and gibbsite

Both reactions run simultaneously and cannot be considered individually in reality, as they are linked and influencing each other, e.g. due to pH-effects and the occurring initial ion release.

Beside the well-known glass ionomer setting reaction, especially the hydration of CA plays a key role since several of Calibra Bio Cements beneficial properties are based on this process. The hydration starts when CA makes contact to water and starts to dissolve into the liquid phase, forming Ca2+, Al(OH)4-and OH-ions (dissolution period). The dissolution of CA is accompanied by the precipitation of small amounts of an amorphous meta-stable AH3-gel and other hydrates. At a certain point the Ca2+concentration and the Ca2+/ Al(OH)4 ratio is sufficient leading to growing of nuclei. In this period, the solution starts to thicken and becomes basic due to excess of OH-ions (nucleation period). At the end of the nucleation period, massive precipitation begins (bulk-precipitation period) followed by transformation of the meta-stable hydrates to the thermodynamically stable minerals katoite (Ca3[Al(OH)4]2(OH)4) and gibbsite(Al(OH)3) (continued simultaneous precipitation/dissolution period). The hydration process is proceeding until all CA or water is consumed.

During the dissolution period, the CA part of Calibra Bio cement dissolves into the liquid phase and the resulting ion-containing solution will penetrate imperfections of the tooth wall. The emerging hydrates will precipitate at pre-existing nuclei and filler particles on the tooth wall. During this process, the surface irregularities are filled by emerging CA hydrates leading to a seamless surface adaptation of Calibra Bio cement towards the tooth structure.

The primary mineral of human tooth enamel and dentin is hydroxyapatite (HA), which is a crystalline calcium phosphate (Ca10(PO4)6(OH)2). The formation of an HA-layer occurs along the preparation margins where Calibra Bio cement is in direct contact to the oral environment. The additional HA layer contributes to an excellent marginal seal and enhances the integrity of the restoration. The HA forming reaction is caused by ion release of the cement (Ca2+ , OH-) in combination with phosphate ions from saliva, but also arises when katoite (product of CA hydration) gets in contact to body-fluid. The growth of HA is slowing down with layer thickness and will stop at a certain point when no more  Ca2+/OHions are diffusing through the existing layer. In case the HA layer is removed or damaged and a relevant amount of ions is available again new HA is formed and precipitated. Therefore, the HA layer can be regarded as a self-repairing layer. 

Product and Technique Guides

Watch our step-by-step video to help guide you in a successful zirconia crown restoration with Calibra Bio cement by seeing how to select the right cement, prepare the crown and tooth, cement the final crown, and cleaning up excess cement.

Discover the clinical benefits and product features of Calibra Bio cement.

See how Calibra Bio cement can help minimize microleakage and enhance your restoration longevity.

See how Calibra Bio cement's bioactive chemistry helps deliver restorations that endure.


Hear what today’s top clinicians have to say about using Calibra Bio cement.

Watch a shorter version of the testimonials video & hear what today’s clinicians have to say about Calibra Bio cement's easy cleanup of excess cement.

Watch a shorter version of the testimonials video & hear what today's clinicians have to say about Calibra Bio cement's unique sealing abilities.


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1. The studies cited refer to Ceramir Crown&Bridgecement, a brand name under which Calibra® Biocementismarketed in some countries.

2. Acharya et al. 2018

3. Jeffries et al. 2013

4. Pameijer et al.2008

5. Pameijer et al. 2010Ceramir Crown & Bridge, Ketac Cem, RelyX Luting Plus, RelyX Unicem, and RelyX Unicem 2 are not registeredtrademarks of Dentsply Sirona, Inc.