The bioactive method of root canal sealing 

ProRoot Bio Sealer is a ready-to-use, pre-mixed and injectable resin-free material, that facilitates its direct application into the root canals.
Designed for cold, warm, and carrier-based techniques1, this bioceramic sealer combines higher bioactive cement content2 compared to other bioceramic sealers with easy handling and minimal waste3. 

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Why choose ProRoot Bio Sealer?

Suitable for all obturation techniques

Delivers consistent performance across cold, warm, and carrier-based methods—plus it’s retreatable4 and non-staining.8

Higher bioactive cement content

Promotes hydroxyapatite formation5 and leads to a high pH value9

Easy handling with minimal waste

The ProRoot Flex Tip enables precise application into complex canals with up to 49% less waste per tip.3

High clinical success rates

Demonstrated very high short term healing rates, more stable radiographic visibility over time and comparable low post-op sensitivity compared to leading bioceramic sealer.6

Connected solutions for bioactive endodontics

SmartLite Pro EndoActivator

Enhance canal cleanliness and sealer integration by pairing ProRoot Bio Sealer with the SmartLite Pro EndoActivator for optimized irrigation.

Conform Fit® Gutta-Percha

Pair ProRoot with Conform Fit gutta-percha points for a snug apical fit and an accurate tug back that you can feel.

Bioactivity meets clinical efficiency

Higher bioactive cement content 

ProRoot Bio Sealer’s calcium silicate-based formulation features higher bioactive cement content 2, compared to other bioceramic sealers, which promotes hydroxyapatite formation5.
High clinical success rates6
  • Very high short term healing rate6
  • More stable radiographic visibility over time compared to leading bioceramic sealer6
  • Post-op sensitivity observed in clinical study similar to AH Plus® and leading bioceramic sealer6
Easy handling with minimal waste 

Innovation extends to ProRoot® Bio Sealer’s applicator, too. Its flexible, adaptable ProRoot® Flex Tip design afforts precise application into all canal anatomies with up to 49% less waste per tip. 3

  • Favorable flowability, syringe extrusion force, and easy application into the root canal7
  • Suitable for all obturation techniques: Cold, warm, carrier based1
  • Easy retreatment4
  • Non-staining formula8
  • High pH value9

How to

Step 1:

Perform final irrigation with distilled water and dry the root canal using paper points. Moisture is required for setting.

Step 2:

Attach the tip to the syringe. If used intraorally, cover with a disposable sleeve to reduce contamination. Test flow by dispensing a small amount onto a pad before use.

Step 3:

Insert the tip into the canal to the desired depth, taking care to not insert the end past the middle third of the root canal. Avoid forcing or sealing the tip against canal walls.

Step 4:

Apply gentle, steady pressure to the syringe plunger with a constant outward movement from the canal as the material is injected.

Step 5:

Proceed with your preferred obturation technique.

Step 6:

Clean and disinfect the syringe per protocol. To prevent hardening, recap immediately and store in the protective aluminum packaging provided. Store at room temperature.

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Frequently asked questions

It contains a higher percentage of bioactive cement content2, which contributes to a high pH9 and promotes hydroxyapatite formation5. This creates an environment which supports healing and sealing.

Yes. It’s suitable for cold, warm, and carrier-based techniques1, offering flexibility for any obutration approach.

Yes. The included ProRoot Flex Tips, which you can optionally bend to an angle you prefer, are designed for precision placement with excellent flowability—even in curved or irregular canals.

Only 0.087 gram, which is up to 49% less waste per tip3 compared to other bioceramic applicators, making it efficient and cost-conscious.

No. It’s a non-staining formula8 and maintains more stable radiographic visibility over time compared to leading bioceramic sealer6, aiding in long-term monitoring.

ProRoot BioSealer is easy to retreat,4 making it a good choice for successful and time efficient retreatment procedures.

Explore Endodontics

Downloads

ProRoot® Bio Sealer | Fact File | EN
This fact file focuses on the physico-chemical properties of the ProRoot ® Bio Sealer, the biological responses and some clinical aspects, providing a comprehensive understanding of its potential in root canal treatment.
1 MB
Download
ProRoot® Bio Sealer | Technique Guide | EN
Step-by-step instructions for the bioceramic endo sealer ProRoot Bio Sealer
53 MB
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For instructions for use, safety data sheets, eMDR documents and more, visit our Download Center

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What dentists say about ProRoot Bio Sealer

"ProRoot Bio Sealer has excellent viscosity allowing me to control placement. It flows into microanatomy and canal irregularities when present. The obturation pops off the screen, giving the postoperative image a dense look with no voids. When a bioceramic sealer is the best alternative, ProRoot Bio Sealer will be my choice."

David J. Landwehr DDS, MS Capital Endodontics, Madison, WI

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1. In vivo case study comparing handling of bioceramic sealers using warm obturation technique, Walsh. External data on file. For more information contact Consumables-Data-Requests@dentsplysirona.com 

2. Based on crystalline portion evaluated by XRD analysis comparing different bioceramic sealers (cf. chart). Internal data on file. For more information contact Consumables-Data-Requests@dentsplysirona.com

3. Tip waste analysis of different bioceramic sealer tips. Internal data on file. For more information contact Consumables-Data-Requests@dentsplysirona.com

4. Carrillo, et al. Retrievability of calcium silicate-based root canal  sealers during retreatment: an ex vivo study. Journal of Endodontics, 48(6), 781–786, February 2022. For more information contact Consumables-Data-Requests@dentsplysirona.com

5. SEM analysis 2025, DS funded, University of Zurich, external data on file. For more information contact Consumables-Data-Requests@dentsplysirona.com

6. Randomized controlled ongoing clinical trial ( >450 follow up cases) comparing bioceramic sealers with AH Plus resin-based sealer, Gustavo De-Deus, University of Rio de Janeiro. External data on file. For more information contact Consumables-Data-Requests@dentsplysirona.com

7. DS conducted professional evaluation, 2024. Internal data on file. For more information contact Consumables-Data-Requests@dentsplysirona.com

8. ProRoot® Bio Sealer does not contain bismuth oxide which is responsible for staining

9. In vitro pH study, demonstrated pH level of up to 11. Internal data on file. For more information contact Consumables-Data-Requests@dentsplysirona.com