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Dentsply Sirona Denmark
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Bone & soft tissue regeneration


Recreating nature

Comprehensive portfolio for guided bone and soft tissue regeneration

Solutions for all your regenerative needs

The comprehensive portfolio for guided bone and soft tissue regeneration provides ease of use and safety for dental clinicians and their patients.

Symbios consists of a full range of reliable bone graft materials, resorbable and non-resorbable membranes and instruments. Designed for the widest range of dental surgery and implant needs, these solutions promote bone formation, volume and stability for predictable, long-term outcomes that patients and dental professionals can rely on.

As always, the focus of development is on making our products simple and easy to use: For accurate, successful and fast work at all times.

Symbios – Bone graft materials

For defects affecting the bone quantity of your patients, bone graft material can help you create new bone or remodel existing ridges. The Symbios product line includes xenograft, allograft and synthetic bone graft material developed to deliver the bone regeneration results you want to achieve.

Symbios Xenograft Granules

Xenograft bone graft material

The osteoconductive hydroxylapatite in xenograft bone regeneration material – analogous to the hydroxylapatite of natural bone – is derived from non-human donors. Xenograft bone graft serves as a framework upon which bone from the surrounding area can grow to fill the defect.

Symbios phycogenic bone graft material

Phycogenic bone graft material

The algae-derived products are very similar to the human bone. All algae-derived (phycogenic) materials demonstrate a high specific porosity up to 1.1 cm3/g. Their unique honeycomb like structure with an interconnected porous channel system and their specific chemistry is decisive for the high in-vivo bioactivity of the phycogenic materials.

Symbios Xenograft Granules

Symbios Xenograft Granules is a porcine bone mineral indicated for periodontal, oral and maxillofacial surgery. The use of Symbios Xenograft Granules may be considered when autogenous bone is not indicated or is insufficient in quantity to fulfill the needs of the proposed surgical procedure.

  • Highly porous carbonate apatite particles
  • Natural pore structure for cell conduction
  • High intra- and inter-particle space for Osteoconduction and new bone deposition
Symbios Biphasic Bone Graft Material (BGM)

Symbios Biphasic Bone Graft Material (BGM)

Symbios Biphasic Bone Graft Material is a resorbable inorganic bone forming material derived from red marine algae. The composition is 20% hydroxyapatite and 80% β-tricalciumphosphate. Due to the high tricalciumphosphate content of the product it resorbs significantly faster than pure hydroxyapatite.

  • Osteoconductive - Bone analogous properties and interconnecting pores
  • Resorption kinetics in the sense of restitutio ad integrum - Material degradation and bone remodeling/healing are balanced. Resorbs almost completely
  • Volume stability - The resorption properties enable volume stability during bone formation
  • Straightforward application - Saturation with patient’s blood and addition of autogenous bone chips improve healing
Symbios Algipore

Symbios Algipore

Highly porous hydroxyapatite – bone reconstruction material derived from red marine algae highly analogous to the hydroxyapatite of the natural bone:

  • Promotes bone formation – osseoconduction due to the interconnecting pores and coarse surface.
  • Resorbs almost completely –Symbios Algipore is a bone regeneration material in the sense of a restitutio ad integrum, i.e. defect free healing.
  • Stable volume – the ideal resorption kinetics create a scaffold with a stable form during the whole bone formation phase.
  • Suitable for the indication – available in three various grain sizes.
  • Straightforward application – mixed with the patient‘s blood.
  • Over 30 years’ clinical experience – Symbios Algipore has been successfully used since 1988, has carried the CE mark since 1998, and has had US FDA approval since 2003.

GBR/GTR membranes

A dental membrane is used to stabilize and contain the defect by preventing gingival tissues from infiltrating the site. As an exception, Symbios PerioDerm Acellular Dermis is used to treat facial recession defects.

Symbios resorbable dental membranes

Resorbable membranes

The Symbios resorbable dental membranes help provide a framework for cellular ingrowth and vascularization, guide bone healing, and prevent cellular and bacterial infiltration. Resorbable membranes are designed to be absorbed, eliminating the need for surgical removal.

Symbios Collagen Membrane SR

Symbios Collagen Membrane SR (slow resorbable) is a bioresorbable, implantable collagen type I originating from bovine Achilles tendon. It is intended for use in dental surgery procedures. The membrane functions as a barrier, aiding in wound healing after dental surgery in cases with a dental implant, a bone defect or ridge reconstruction. Fiber matrix construction allows tissue integration, while preventing direct passage of bacteria and epithelial cells.

  • Safe for the patient - Highly purified collagen type I derived from bovine Achilles tendon
  • Prevents epithelial downgrowth - Cell occlusive
  • You can suture or tack the membrane in place without tearing - Unique fiber orientation provides high tensile strength
  • Stiff enough for easy placement, yet easily drapes over ridge - Optimized flexibility. Can be placed either dry or hydrated

Symbios Collagen Membrane pre-hydrated 

Symbios Collagen Membrane pre-hydrated consists of purified intact collagen tissue derived from bovine pericardium. The unique pre-hydrated delivery makes immediate use possible; it is flexible and easily contours to the defect.

  • Semi-permeable; permeable to nutrients and macromolecules
  • Intact tissue provides high mechanical strength for resistance to suture pull-out
  • Acts as a cell barrier to prevent epithelial down growth into the bone defect site
  • Approximately 0.5 mm thick membrane
  • Can easily be trimmed during surgery for a final fit

Dental bone graft instruments & accessories 

Symbios offers a selection of instruments to support your bone regeneration processes. Included are solutions for harvesting your patients own bone (autologous bone graft material) and preparing bone blocks and access windows.

Symbios dental bone graft instruments & accessories

Efficiency is one key in providing a quick and atraumatic patient experience, and reducing the risk of adverse events. The Symbios instrument portfolio has been developed to increase the success of your bone grafting and regeneration procedures.

Frios MicroSaw Set

Frios MicroSaw Set

Fast and atraumatic preparation of bone blocks and access windows:

  • High precision 0.29 mm MicroSaw disc constructed to produce an accurate osteotomy line.
  • Fast – rapid work with the Frios straight and contra-angle handpieces. Even for the most difficult anatomical situations.
  • Easy – with the Frios angled handpiece the exact preparation can be made in the retromolar region, even with restricted mouth opening.
  • Atraumatic – the hinged soft tissue protector is easy to attach and to remove again. Direct blade cooling prevents overheating during the procedure.
  • Proven – in clinical use since 1986.
Frios FixationSet

Frios FixationSet

  • A complete instrument set for precise positioning of Frios Membrane Tacks:
  • Fast and precise – accurately coordinated instrument set for the placement of Frios Membrane Tacks.
  • Finest disposable drills – for predrilling into very hard bone.
  • Complete – the tray also contains the Frios drilling and positioning tool.
Frios SinusSet

Frios SinusSet

  • Clearly displayed – all instruments are color-coded and arranged in order of use.
  • Preparation of the lateral bone window – from large, diamond-coated round drills to fine fissure drills, all rotary instruments are at hand.
  • Mobilization of the sinus mucous membrane – with a range of angled elevators.
  • Blending the augmentation material – in the stable surgical blending beaker.
  • Filling the maxillary sinus – using various surgical applicators.


Harvesting vital bone chips in parallel with the preparation of the dental implant site:

  • Simplifies the procedure of collecting and using autologous bone.
  • Eliminates immunological reactions associated with bone substitute materials.
  • Reduces the need for costly artificial material.
  • Saves time – delivered sterile and is disposable.

Frios Trephines

Trephines for preparation of autogenous bone cones

Frios BoneStud Remover

Bone Stud Remover for easy removal of the bone pieces.

During guided bone/tissue regeneration therapies, dental membranes need to stay where placed. The following accessories are designed to give the new-forming bone a chance to heal undisturbed.

Symbios Membrane Tacks

Symbios Membrane Tacks

  • Perfect hold – well attached membranes prevent the dislocation of the material and promote the formation of new bone.
  • Fabricated from a titanium alloy and gamma sterilized.
  • Can be used with all resorbable and non-resorbable membranes.
  • Frios FixationSet used for placing Frios Membrane Tacks.

Symbios downloads

Symbios Product catalog

Case Report on peri-implantitis treatment with Algipore 396 kB

15-year follow-up of peri-implantitis treatment and bone regeneration with Algipore.— A 70 year old woman (healthy and former smoker) was referred to the clinic with radiographic bone loss around implant 14. The implant had been in place for 5 years...

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